Fig. 5.

Effects of the 5-HT_2C antagonist SB 242084 on fluoxetine-induced exaggerated shock-elicited freezing. SB 242084 (1 mg/kg) was administered 15 min prior to saline or fluoxetine (10 mg/kg). Freezing behavior immediately before (pre-shock) and immediately following (representing fear conditioned to contextual or discrete cues in the shuttle box) three foot shocks was assessed in a shuttle box 1 h later. Data are presented as a 2-min blocks of freezing and b the mean percent shock-elicited freezing for the entire 20-min observation period. Data are means ± SEM. Asterisk p<0.05 relative to saline, SB 242084, and SB 242084/fluoxetine groups. The number in each bar represents the number of animals included in that group