Fig. 6.

Effects of the 5-HT_2C antagonist SB 242084 on fluoxetine-induced escape deficit. SB 242084 (1 mg/kg) was administered 15 min prior to saline or fluoxetine (10 mg/kg). Rats were placed into shuttle boxes for assessment of fixed-ratio 1 (FR-1) and fixed-ratio 2 (FR-2) escape performance 1 h later. Data are presented as a blocks of five escape trials and b the mean escape latency for all 25 FR-2 escape trials. Data represent means ± SEM. Asterisk p<0.05 relative to saline, SB 242084, and SB 242084/fluoxetine groups. Group sizes are shown within the bars