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. Author manuscript; available in PMC: 2015 Mar 11.
Published in final edited form as: Eur J Neurosci. 2013 Jan 29;37(6):982–995. doi: 10.1111/ejn.12121

Figure 5. Blockade of AMPA receptors prevents the augmented locomotor response to cocaine in pre-stress animals.

Figure 5

The number of rats in each group (non-stress/vehicle, non-stress/CNQX, stress/vehicle, stress/CNQX) is 5–8. Data are shown as the mean +/− SEM horizontal photocell counts. A Total horizontal photocell counts 120 min after DMSO microinjection (0.1, 1.0, 10 %) or CNQX (0.01, 0.1, 1.0 nmol) associated with a saline or cocaine (15 mg/kg i.p.) injection. Data were analyzed by a two-way ANOVA (non-stressed/stressed x dose) with repeated measures over dose. Interaction, F(11,91)=2.69, p<0.01; treatment, F(1,91)=20.80, p<0.0001; dose, F(11,91)=26.87, p<0.0001; *p<0.05, **p<0.01, ***p<0.001, comparing stress to control using a Bonferroni post-hoc test. T-test(5)=3.48, p<0.05, showed significant difference between the stress group at DMSO (10 %) and CNQX (1 nmol). B Time-course of the horizontal photocell counts shown in the top panel corresponding to DMSO 1 % plus cocaine. Time-frame 10 to 60 min corresponds to the acclimation period before DMSO plus cocaine administration at 70 min. Data were analyzed by a two-way ANOVA (non-stressed/stressed x time) with repeated measures over time. Interaction, F(17,170)=2.33, p<0.01; treatment, F(1,170)=10.13, p<0.01; time, F(17,170)=8.49, p<0.001; *p<0.05, **p<0.01, ***p<0.001 comparing stress to control using a Bonferroni post-hoc test. C Time course of the horizontal photocell counts shown in the top panel corresponding to CNQX 0.1 nmol plus cocaine. Time-course: 10 to 60 min corresponds to the 60 min corresponds to the acclimatation period before CNQX plus cocaine administration at 70 min. D Time-course of the horizontal photocell counts shown in the top panel corresponding to DMSO 10 % plus cocaine. Data were analyzed by a two-way ANOVA (non-stressed/stressed x time) with repeated measures over time. Interaction, F(17,221)=2.58, p<0.001; treatment, F(1,221)=11.49, p<0.01; time, F(17,221)=18.42, p<0.001; *p<0.05, **p<0.01, ***p<0.001 comparing stress to control using a Bonferroni post-hoc test. E Time-course of the horizontal photocell counts shown in the top panel corresponding to CNQX 1 nmol plus cocaine.