Table 1.
Neocartilage Wet Weight, Water Content, Glycosaminoglycan Content, Cells/Construct, and Pyridinoline Per Collagen Content at the End of 4 Weeks of Culture
| Group | Wet weight (mg) | Water content (%) | GAG/WW (%) | Cells/construct (millions) | PYR/collagen (nmol/mg) |
|---|---|---|---|---|---|
| Control | 38.5±1.5c | 85.1±1.5ab | 4.1±0.6a | 5.8±0.2ab | 1.36±0.24a |
| Ouabain | 32.6±1.0d | 87.1±3.2a | 4.7±1.2a | 5.1±0.6bc | 0.83±0.15cd |
| Digoxin (low) | 41.6±3.5ab | 84.9±1.6ab | 3.5±0.4bc | 6.1±0.5a | 1.07±0.21b |
| Digoxin (high) | 33.1±3.2d | 86.4±2.0a | 2.5±0.2c | 4.5±0.4c | 0.81±0.20cd |
| ATP | 41.7±1.7a | 85.0±1.4ab | 4.0±0.8a | 5.8±0.4ab | 0.68±0.11d |
| Digoxin (low)+ATP | 40.0±2.5abc | 86.6±1.2a | 3.3±0.6bc | 5.7±0.7ab | 1.06±0.21b |
| Digoxin (low)+KB-R7943 | 38.9±2.5bc | 83.5±2.2b | 3.9±0.6ab | 6.1±0.7a | 0.75±0.18cd |
| ATP+suramin | 40.5±1.7abc | 83.3±1.3b | 4.2±1.0a | 5.5±0.8ab | 0.83±0.23bcd |
Significant differences (p<0.05) exist between groups not sharing the same letters.
PYR/collagen, pyridinoline per collagen; ATP, adenosine triphosphate.