Figure 3.
Doses and concentrations of pyrazinamide achieved in 31 South African children. A P value ≥0.05 is significant for a normal distribution. (a) The ratio of the lowest-to-highest pyrazinamide dose was 2.8-fold, with a large proportion of doses below the WHO-recommended doses. (b) The 2 h pyrazinamide concentration had a lowest-to-highest ratio of 28.3, severalfold higher than the ratio for the dose. (c) The peak pyrazinamide concentration had a lowest-to-highest ratio of 4.2, which was thus lower than the variability of the pyrazinamide 2 h concentration. (d) The pyrazinamide AUC0–24 that was achieved varied 4.8-fold between the lowest and highest concentrations.