Table 2.

PK parameter estimates for first-line anti-TB drugs in South African children

	Isoniazid	Rifampicin	Pyrazinamide	Ethambutol
Total clearance (L·h−1)	12.2 (7.58)	12.7 (9.9)	2.7 (0.9)	20.6 (6.1)
Volume of central compartment (L)	56.4 (7.5)	85.1 (42.7)	24.0 (2.3)	135 (21.2)
Absorption constant (h−1)	10.0 (4.4)	14.8 (7.4)	0.9 (0.3)	1.7 (2.1)
Intercompartmental clearance (L·h−1)	10.2 (2.8)	NA	NA
Volume of peripheral compartment (L)	1.0 (0.3)	NA	NA

NA, not applicable for a one-compartment model.

Values are shown as mean (±SD).