FIG. 6.

Angiogenesis at the transplantation area in the kidney subcapsule after transplantation of both ICCs and HSs (IC:hMSC=10:1). (a) CD31-positive (green) microvessels with insulin-positive (red) transplanted ICs (left panel). The kidneys that contained transplanted islets were harvested 14 and 28 days after the transplantation. Arrows indicate CD31-positive microvessels in the transplantation region. Blue indicates nuclei stained with DAPI. Scale bars=100 μm. Right panel. The density of CD31-positive microvessels in the insulin-positive region. *p<0.05 compared with ICCs. (b) Whole-mount immunostaining of CD31 (green) and insulin (red) in the transplantation area. The kidneys containing transplanted islets were harvested 28 days after the transplantation. Scale bars=100 μm. Color images available online at www.liebertpub.com/tea