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HSP70 is an inducible chaperone protein that can be provide protection against muscle atrophy in several ways. (1) Refolding of misfolded or unfolded proteins, (2) inhibiting select pathways of protein degradation, (3) maintaining mitochondrial integrity and reducing apoptosis by preventing the release of cytochrome C from mitochondria, and (4) improving translation elongation and promoting protein synthesis.
