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. Author manuscript; available in PMC: 2016 Feb 12.
Published in final edited form as: Cell. 2015 Jan 29;160(4):595–606. doi: 10.1016/j.cell.2015.01.009

Figure 7. A Family of SERCA-inhibitory Micropeptides.

Figure 7

(A) The Ca2+ pumps, RyR and SERCA, play a critical role in muscle contractility by controlling Ca2+ cycling between the cytosol and SR. MLN, PLN and SLN inhibit SERCA pump activity in different striated muscle types of vertebrates.

(B) Illustration of the family of SERCA-inhibitory micropeptides. The discovery of MLN reveals that vertebrates encode three SERCA-inhibitory peptides that share conserved residues within their transmembrane alpha helices. Green shading denotes identical residues and blue denotes similar residues. MLN, myoregulin; PLN, phospholamban; SLN, sarcolipin; SCL, sarcolamban.