Table I.
Differentially-expressed and methylated genes in tumor tissues compared with the normal tissues of patients with cervical cancer.
| Gene | Accession number | Name | Δ value | Fold change | CCDB | GENT |
|---|---|---|---|---|---|---|
| Downregulated genes by hypermethylation in cancer | ||||||
| SYT11 | NM_152280.2 | Synaptotagmin XI | 0.32 | −2.70 | NA | Down |
| CAMK2N1 | NM_018584.4 | Calcium/calmodulin-dependent protein kinase II inhibitor 1 | 0.28 | −4.95 | NA | Up |
| ALDH1A3 | NM_000693.1 | Aldehyde dehydrogenase 1 family, member A3 | 0.27 | −3.08 | NA | Not changed |
| PRRX1 | NM_006902.3 | Paired related homeobox 1, transcript variant pmx-1a | 0.25 | −3.18 | NA | Down |
| PPP1R3C | NM_005398.3 | Protein phosphatase 1, regulatory (inhibitor) subunit 3C | 0.22 | −6.18 | Down | Down, highly |
| MAP1LC3A | NM_181509.1 | Microtubule-associated protein 1 light chain 3α, transcript variant 2 | 0.22 | −3.14 | NA | Down |
| PHF21B | NM_138415.1 | PHD finger protein 21B | 0.20 | −2.06 | NA | Down, highly |
| TPM1 | NM_001018004.1 | Tropomyosin 1 (α), transcript variant 7 | 0.20 | −2.07 | NA | Down, highly |
| PPP1R14A | NM_033256.1 | Protein phosphatase 1, regulatory (inhibitor) subunit 14A | 0.20 | −2.91 | NA | Down, highly |
| Upregulated genes by hypomethylation in cancer | ||||||
| PLOD2 | NM_000935.2 | Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2, transcript variant 2 | −0.25 | 2.66 | Up | Up, highly |
| FAT1 | NM_005245.3 | FAT tumor suppressor homolog 1 (Drosophila) | −0.23 | 3.44 | NA | NA |
| EXT1 | NM_000127.2 | Exostoses (multiple) 1 | −0.22 | 2.40 | NA | Up |
| TMEM44 | NM_138399.3 | Transmembrane protein 44, transcript variant 1 | −0.21 | 3.02 | NA | Up |
| Downregulated genes by hypermethylation in pre-cancer | ||||||
| SNCAIP | NM_005460.2 | Synuclein, alpha interacting protein | 0.23 | −2.39 | NA | Down |
| A2M | NM_000014.4 | α-2-macroglobulin | 0.21 | −2.22 | Up | Down |
| CGNL1 | NM_032866.3 | Cingulin-like 1 | 0.21 | −3.14 | NA | Down, highly |
| DLC1 | NM_024767.2 | Deleted in liver cancer 1, transcript variant 3 | 0.20 | −2.45 | Down | Down, highly |
| RNF150 | NM_020724.1 | Ring finger protein 150 | 0.20 | −2.18 | NA | Down, highly |
| Upregulated genes by hypomethylation in pre-cancer | ||||||
| MUC4 | NM_018406.3 | Mucin 4, cell surface-associated, transcript variant 1 | −0.21 | 2.94 | NA | Up |
CCDB, cervical cancer database; GENT, gene expression database across normal and tumor tissues; NA, not applicable.