Table II.
Functional annotation clustering (gene ontology) of 19 selected genes showing five clusters.
| Annotation cluster | Enrichment category | Count | P-value | False discovery ratea |
|---|---|---|---|---|
| 1 | ||||
| GOTERM_CC_FAT | Cell junction | 4 | 1.70×10−2 | 8.20×10−1 |
| GOTERM_CC_FAT | Plasma membrane part | 7 | 2.20×10−2 | 6.80×10−1 |
| GOTERM_CC_FAT | Plasma membrane | 7 | 2.10×10−1 | 9.30×10−1 |
| 2 | ||||
| GOTERM_CC_FAT | Cytoskeletal part | 4 | 8.10×10−2 | 8.10×10−1 |
| GOTERM_CC_FAT | Cytoskeleton | 4 | 1.90×10−1 | 9.20×10−1 |
| GOTERM_CC_FAT | Intracellular non-membrane-bound organelle | 4 | 5.60×10−1 | 1.00 |
| GOTERM_CC_FAT | Non-membrane-bound organelle | 4 | 5.60×10−1 | 1.00 |
| 3 | ||||
| SP_PIR_KEYWORDS | Membrane | 9 | 2.00×10−1 | 9.60×10−1 |
| GOTERM_CC_FAT | Integral to plasma membrane | 3 | 3.80×10−1 | 9.90×10−1 |
| GOTERM_CC_FAT | Intrinsic to plasma membrane | 3 | 3.90×10−1 | 9.90×10−1 |
| UP_SEQ_FEATURE | Topological domain: Cytoplasmic | 5 | 4.00×10−1 | 1.00 |
| UP_SEQ_FEATURE | Transmembrane region | 6 | 5.10×10−1 | 1.00 |
| SP_PIR_KEYWORDS | Transmembrane | 6 | 5.20×10−1 | 9.90×10−1 |
| GOTERM_CC_FAT | Intrinsic to membrane | 7 | 6.00×10−1 | 1.00 |
| UP_SEQ_FEATURE | Topological domain: Extracellular | 3 | 7.50×10−1 | 1.00 |
| GOTERM_CC_FAT | Integral to membrane | 6 | 7.60×10−1 | 1.00 |
| 4 | ||||
| UP_SEQ_FEATURE | Glycosylation site: N-linked (GlcNAc) | 6 | 3.50×10−1 | 1.00 |
| SP_PIR_KEYWORDS | Signal | 5 | 3.60×10−1 | 9.90×10−1 |
| UP_SEQ_FEATURE | Signal peptide | 5 | 3.70×10−1 | 1.00 |
| SP_PIR_KEYWORDS | Glycoprotein | 6 | 3.80×10−1 | 9.90×10−1 |
| UP_SEQ_FEATURE | Disulfide bond | 3 | 7.70×10−1 | 1.00 |
| SP_PIR_KEYWORDS | Disulfide bond | 3 | 7.80×10−1 | 1.00 |
| 5 | ||||
| SP_PIR_KEYWORDS | Metal-binding | 4 | 5.40×10−1 | 9.90×10−1 |
| GOTERM_MF_FAT | Metal ion binding | 5 | 8.00×10−1 | 1.00 |
| GOTERM_MF_FAT | Cation binding | 5 | 8.10×10−1 | 1.00 |
| GOTERM_MF_FAT | Ion binding | 5 | 8.20×10−1 | 1.00 |
| GOTERM_MF_FAT | Transition metal ion binding | 3 | 8.90×10−1 | 1.00 |
a
Using the Benjamini method. κ similarity (similarity term overlap, 3; similarity threshold, 0.50); classification (initial group membership, 3; final group membership, 3; multiple linkage threshold, 0.50); enrichment thresholds (ease 1.0). Enrichment scores for the five annotation clusters were as follows: 1, 1.37; 2, 0.58; 3, 0.33; 4, 0.33; and 5, 0.12.