Table 1. Differentiation of many cell types involves caspases.

Progenitor cells	Caspase activation	Mechanism	Reference (s)
Erythroid cells	Caspase-2, -3 and -9	Cleavage of lamin B and acinus	84
Keratinocytes	Caspase-3	Terminal differentiation of embryonic cells involving Casp3-Notch1 mechanism	102
Lens cells	Caspase-14	Caspase-14 induction and processing during differentiation of keratinocytes	98, 99
	Caspase-3	Lens fiber formation	83
Muscle progenitor cell	Caspase-3 and -9	Muscle fiber formation	87, 88
Bone marrow stromal stem cells	Caspase-3	Osteoblasts and bone formation involving TGFβ signaling	89
Osteoblasts	Caspase-2, -3 and -8	Activation of caspases in differentiating cells	90
Odontoblasts	Caspase-7	Activation of caspase-7 in bone-forming cells	91
Monocytes (bone marrow)	Caspase-3, -8 and -9	Macrophage formation	94
Neurons	Caspase-3	Neuronal differentiation, migration and plasticity	85
Embryonic stem cells	Caspase-3	Caspase-3-mediated cleavage of Nanog	92
Haematopoietic stem cell	Caspase-3	Maintenance of stem-cell quiescence and response to external stimuli	93