. 2014 Dec 19;22(4):526–539. doi: 10.1038/cdd.2014.216

Table 2. Non-apoptotic roles of caspases in neuronal function.

Process	Caspase	Mechanism	Reference
Dendritic pruning	Caspase-2	Activation of Rho/ROCK-II	²⁰⁰
	Caspase-3	Activation of caspase-3	¹⁹⁹
Axon guidance and synaptogenesis	Caspase-3 and -6 are involved in axonal guidance and synapse formation	Mice lacking caspase-3 and -6 have developmental delay in pruning retinocollicular axons	²⁰²
	Caspase-9 and Apaf regulate synapse formation	Casp9^−/− and Apaf^−/− mice have misrouted axons, impaired synapse and defects in olfaction. Cleavage of semaphorin 7A is vital for proper projection of axons	²⁰¹
Normal synaptic plasticity and function	Caspase-3 is important in LTD	Caspase- 3-mediated internalization of AMPA	²⁰³