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The Map3k1 PHD motif regulates Tabs in response to cytokine stimulation. Following Tgf-β treatment, the Map3k1 PHD motif binds and transfers Lys63-linked poly-Ub onto Tab1 to enhance Map3k7 activation. Tab2, although not a Map3k1 PHD motif substrate, can be recruited to the Map3k1:Map3k7 Ub signaling complex by the Ub binding ZnF motif of Tab2.
