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. 2015 Jan 23;22(4):540–548. doi: 10.1038/cdd.2014.239

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Copyright © 2015 Macmillan Publishers Limited

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The signal transduction role for the Map3k1 PHD motif during cell survival or apoptosis. In response to Tgf-β or Egf cytokines Map3k1 ubiquitinates Tab1 with Lys63-linked poly-Ub to activate Map3k7 and Mapk. This promotes both the differentiation and survival of stem cells. In response to hyperosmotic stress, stem cells enter apoptosis and the Map3k1 PHD motif transfers Lys48-linked poly-Ub onto itself, in conjunction with other E3 Ub ligases, to potentiate the degradation of the Mapk signaling cascade by the proteasome.