Figure 6.

The fully glycosylated form of LLT1 forms hexamers in crystals which are an assembly of three classical dimers. The dimers are distinguished by colour (dark and light green, dark and light blue and black and white). (a) A general view of the hexamer. (b) Visualization of the tunnel and the central cavity of the hexamer (computed in CAVER). A view perpendicular to the threefold axis, which is the direction of the tunnel. (c) Dimer–dimer contacts in the hexamer. One dimer of the hexamer is omitted to show the mutual orientation of two dimers. The N- and C-termini of the chains are denoted. (d) Contact residues of a dimer with its neighbour in the hexamer. Residues forming the LLT1 dimer–dimer contact up to a distance of 5 Å are shown in magenta. Residue Lys169 (important for interaction in the NKR-P1–LLT1 complex) is coloured orange. The contact residues are localized on the termini-distal side. Interacting residues were identified using NCONTACT from the CCP4 package (Winn et al., 2011 ▶).