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Upper panel: cartoon representation of the PaFPPS homodimer with chain A coloured from blue to red from the N-terminus to the C-terminus. Chain B is shown in grey. Helices are labelled A–J. Lower panel: a 90° rotation about a horizontal axis to show the layered topology of the PaFPPS dimer. In chain B (grey) the S1 binding site for inhibitors such as ibandronate and the allosteric site are indicated by an asterisk (S1 site) and a triangle (allosteric site).
