Table 1. Characteristics of the subset of 32 young and older adults in the test cohort selected from 72 participants for gene expression microarray analysis using a stringent definition of vaccine response. Note that four participants in the older group (all vaccine non-responders) met criteria for frailty.
| Patient Characteristics(N=32) | Young(N=12) | Older(N=20) | Probabilitya |
|---|---|---|---|
| Age (years) range (22-93), mean (SD) | 25.75 (2.56) | 75.10 (7.09) | <0.0001 |
| Female, n (%) | 6 (50.00) | 6 (50.00) | 1.000 |
| Non-white Race, n (%) | 4 (33.33) | 4 (20.00) | 0.4325 |
| Influenza Vaccine Responderb, n (%) | 5 (41.67) | 6 (30.00) | 0.7026 |
| Number of Comorbid Conditions, mean (SD) | 0.58 (0.90) | 3.85 (1.98) | <0.0001 |
| Number of Prescription Medications, mean (SD) | 0.50 (0.67) | 4.50 (2.04) | <0.0001 |
| Number of OTC Medications, mean (SD) | 0.67 (0.78) | 3.65 (1.76) | <0.0001 |
| Aspirin, n (%) | 0 (0.00) | 14 (70.00) | 0.0003 |
| Statin Medications, n (%) | 0 (0.00) | 13 (65.00) | 0.0011 |
a
Probability for Student t-test (Continuous Measures), Chi-square test/Fisher's Exact test (Categorical Measures)
b
A vaccine responder had a four-fold increase in hemagglutination inhibition (HAI) titer to at least two of the three strains in the seasonal vaccine. The remaining participants analyzed were all nonresponders without a four-fold increase in HAI titer to any strain in the vaccine.