Table I.
WWOX increases chemosensitivity of ovarian cancer stem cells to chemotherapeutic drugs following gene transfection.
| Relative cell viability, mean ± standard deviation | ||||||
|---|---|---|---|---|---|---|
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| Cisplatin | Doxorubicin | Mitoxantrone | ||||
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| Cell group | 0.25 μg/ml | 0.5 μg/ml | 0.5 μmol/l | 1.5 μmol/l | 0.05 μg/ml | 0.25 μg/ml |
| WWOX-expressing cells | 0.593±0.136 | 0.372±0.136 | 0.461±0.092 | 0.266±0.004 | 0.396±0.101 | 0.103±0.136 |
| Empty-vector cells | 0.823±0.103 | 0.731±0.167 | 0.782±0.133 | 0.601±0.007 | 0.702±0.141 | 0.424±0.002 |
| Untransfected cells | 0.861±0.201 | 0.702±0.129 | 0.841±0.211 | 0.582±0.121 | 0.631±0.161 | 0.371±0.003 |
WWOX, WW domain-containing oxidoreductase.