Table II.

Effect of [D-Try⁶,β-Ala¹¹,Phe¹³,Nle¹⁴]bombesin_6–14 and insulin on glucose transport and glycogen synthase a activity in myocytes from patients with obese/type 2 diabetes (OB/T2D).

	Control no peptide	% of paired control [D-Try6,β-Ala11,Phe13,Nle14]bombesin6–14						Insulina
		10−12 M	10−11 M	10−10 M	10−9 M	10−8 M	10−7 M	10−8 M/10−9 M
Glucose transport	15.7±2.4 fmol/2×104 cells	133±9	160±9a	146±12a	147±9a	167±14a	130±8	202±9a,b
Glycogen synthase a	0.020±0.001 U/g	–	165±16a	153±11a	140±10a	142±11a	–	147±9a

Results are the means ± SEM; n=4

^ap≤0.008 vs. control;

^bp=0.009 vs. treatment with 10⁻¹¹ M [D-Try⁶,β-Ala¹¹,Phe¹³,Nle¹⁴]bombesin_6–14. ^aThe maximal effect on glucose transport was induced by 10⁻⁸ insulin; in signaling and metabolic assays (i.e., glycogen synthase a activity), the maximal effect induced by insulin was achieved at 10⁻⁹.