Table 3.

 Type of harm expected from potentially serious drug-drug interaction for each index condition

Index condition	Cardiovascular*	Bleeding	Renal/potassium	Central nervous system	Other†	Total
Type 2 diabetes
First line recommended drug	3	3	2	0	12	20
Second line recommended drug	54	11	18	1	29	113
Depression
First line recommended drug	1	9	0	7	2	19
Second line recommended drug	10	13	0	27	20	70
Heart failure
First line recommended drug	15	0	4	0	2	21
Second line recommended drug	17	34	17	0	22	90

*Includes effects on heart rate or rhythm or effects on blood pressure.

†Includes myopathy with statin treatment, or clinically relevant altered plasma concentration (for example, of digoxin, lithium, ciclosporin, or theophylline), which might require dose alteration or closer monitoring.