FIG. 8.

Coronal suture regeneration in control and TGFβ1-treated groups. Bright-field H and E and pentachrome images obtained with 10× objective. Note regeneration of coronal suture in an 18-week-old control and in 6-week-old TGFβ1-treated rabbits. The neocoronal suture appears highly cellular and vascularized with interdigitating collagen fibers. Bone edges are maintained at a fixed distance with horizontally ordered osteoblasts lined along the neocoronal suture. Limited bone remodeling (red stain) is depicted in the 6-week-old TGFβ1-treated defect (lower right panel) as compared with remodeling in the 18-week-old control defect (upper right panel).