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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: J Psychopharmacol. 2014 Jul 16;28(10):935–946. doi: 10.1177/0269881114542856

Figure 5.

Figure 5

VU-29 (1 μM) enhanced CCH-mediated (20 μM) increases in sIPSCs. (a) Raw traces (5 second sweeps overlaid) of control (left), during DHPG (100 μM); MTEP (10 μM); CCH or CCH combined with VU-29 (centre) and together with BMI (5 μM) and 2-HS (20 μM; right). (b) Percent changes in peak, number of sIPSCs and instantaneous frequency from left to right. Top: DHPG resulted in substantial increases in the peak and total number of sIPSCs but this was not significant (left; n = 26) while MTEP resulted in minimal change (right; n = 20). Significant increases in the peak and total number of sIPSCs following CCH were considerably enhanced when combined with VU-29 (bottom; n = 17; *p < 0.05). In addition, the combination of CCH and VU-29 resulted in significant increases in instantaneous frequency (*p < 0.05).