TABLE 2. Genetic Findings in Suicide.
| Systema | Genes | Paper | Sample | Findings |
|---|---|---|---|---|
| CRH-HPA | FKBP5 | Supriyanto et al. (25) | Japanese | Higher frequency of TC haplotype associated with higher transcription of FKBP5 in suicide victims compared with live nonpsychiatric controls |
| NE-LC | ADRA2 | Fukutake et al. (37) | Japanese | C-allele of C-1291G SNP (unknown function) more prevalent in female suicide victims than in live female nonpsychiatric controls |
| MAO-A | Du et al. (46) | Hungarian | High activity-related allele of EcoRV polymorphism differed in depressed male but not female suicide victims compared with deceased nonpsychiatric controls |
|
| COMT | Ono et al. (48) | Japanese | High activity Val/Val genotype of 158Val/Met polymorphism found less prevalent and Val/Met genotype more prevalent in male but not female suicide victims compared with living nonpsychiatric controls |
|
| COMT | Du et al. (51) | Hungarian | No difference in allele frequency or genotypic distribution in depressed suicide victims compared with deceased nonpsychiatric controls |
|
| COMT | Pivac et al. (49) | Slovenian | Val/Val and Val/Met genotypes of 158Val/Met polymorphism more prevalent in male but not female suicide victims, as compared with deceased controls |
|
| Endogenous opioid |
OPRM1 | Hishimoto et al. (71) | Japanese | The A/A genotype of the A118G SNP, linked to increased binding was more frequent in suicide victims than in live healthy controls |
| Serotonin | TPH2 | Zill et al. (91) | German | SNP rs1386494 (located between exon 5 and exon 7) associated with suicide in a sample of suicide victims compared with live healthy controls |
| TPH2 | Lopez de Lara et al. (92) |
French-Canadian | T allele of SNP rs4448731 and G allele of rs6582071 in upstream region, G allele of rs4641527 in intron 1, and C allele of rs1386497 in intron 8 more prevalent in depressed suicide victims compared with live depressed patients |
|
| TPH2 | Stefulj et al. (93) | Croatian | No difference in genotype or allele frequency of G-703T SNP in sample of suicide victims compared with controls |
|
| TPH2 | Mouri et al. (94) | Japanese | No difference in genotype or allele frequency of 15 tagging SNPs in suicide victims compared with live healthy controls |
|
| TPH1, TPH2, SLC6A4 | Buttenschøn et al. (102) |
Danish | No significant association of either TPH1, TPH2, or 5-HTTLPR with suicide in a sample of suicide victims compared with living controls |
|
| TPH, 5-HTT | Jernej et al. (103) | Croatian | Co-occurrence of 5-HTT intron 2 VNTR 10 allele and CC variant of TPH intron 7 A218C SNP more frequent in suicide victims than in live healthy controls |
|
| 5-HTT | Bondy et al. (171) | German | S allele and homozygous SS genotype of 5-HTTLPR more prevalent in suicide victims than in healthy living controls |
|
| 5-HTT | Lopez de Lara et al. (101) |
French-Canadian | VNTR STin2 allele 10 more frequent in depressed suicide victims compared with depressed controls; no significant genotypic or allelic differences noted at 5-HTTLPR locus |
|
| 5-HTT | Hranilovic et al. (105) | Croatian | No difference in allele and genotype frequency in either 5-HTTLPR or VNTR intron 2 polymorphisms in suicide victims compared with live healthy controls |
|
| 5-HTR1A | Videtic et al. (172) | Slovenian | No difference in C-1019G allele or genotype distributions between suicide victims and deceased controls |
|
| 5-HTR1B | Zouk et al. (114) | French-Canadian | Higher frequency of T allele at A-161T locus in suicide victims compared with live nonpsychiatric controls; no differences atT-261G, C129T, G861C, or A1180G loci |
|
| 5-HTR1B, 5-HTR1Dα, 5-HTR1E, 5-HTR1F, 5-HTR2C, 5-HTR5A, 5-HTR6 |
Turecki et al. (117) | French-Canadian | No difference in allele or genotype frequencies in any loci examined (G861C of 5-HTR1B, T1350C of 5-HTR1Dα, C117T of 5-HTR1E, C-78T and C528T of 5-HTR1F, G-995A of 5-HTR2C, G-19C of 5-HTR5A, and C267T of 5-HTR6) in suicide victims compared with live healthy controls |
|
| 5-HTR2A | Ono et al. (119) | Japanese | No association between 5-HTR2A A-1438G SNP and suicide |
|
| 5-HTR2A | Turecki et al. (111) | French-Canadian | No difference in T102C or A-1438G SNP allele or genotype distribution in suicide victims compared with deceased controls |
|
| 5-HTR2C | Videtic et al. (116) | Slovenian | Increased frequency of G68C G-allele and GG genotype in suicide victims compared with controls; relationship also significant in females but not males; no association between G-995A and suicide |
|
| 5-HTR6 | Azenha et al. (115) | Portuguese | Difference in C267T genotype distribution in male suicide victims compared with deceased nonpsychiatric controls; no association present when females included |
|
| Neuronal plasticity |
BDNF | Pregelj et al. (168) | Slovenian | No difference in Val66Met variant distribution in suicide victims compared with deceased controls; in females, more likely to have Met alleles associated with low activity |
| DISC1 | Ratta-apha et al. (173) |
Japanese | Allele frequency and genotype distribution of Ser704Cys variant differ in suicide victims and live healthy controls |
a
CRH-HPA=corticotropin-releasing hormone/hypothalamic-pituitary-adrenal axis system; LC-NE=locus ceruleus-based norepinephrine system.