A) Representative images from vehicle-treated (left panels) and BDNF-treated mice (right
panels). At low magnification (upper panels, scale bars 100μm) glomeruli with
segmental sclerosis (red arrows) and dilated tubuli filled by proteinaceous material
(white arrows) can be observed in the renal tissue from a vehicle treated mouse. Tubular
dilation (yellow arrow) is still present after BDNF treatment, but protein casts are no
more visible, and glomeruli have a normal appearance. These features can be better
appreciated at higher magnification (lower panels, scale bars 50μm).
B) Transmission (upper panels) and scanning (lower panels) electron microscopy pictures
show completely flattened podocyte processes from a vehicle-treated animal, and their
almost normal appearance after BDNF treatment (scale bars: 5μm).