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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: J Pathol. 2015 Jan 7;235(5):731–744. doi: 10.1002/path.4484

Fig 5. BDNF treatment in mouse adriamycin nephropathy.

Fig 5

A) Representative images from vehicle-treated (left panels) and BDNF-treated mice (right panels). At low magnification (upper panels, scale bars 100μm) glomeruli with segmental sclerosis (red arrows) and dilated tubuli filled by proteinaceous material (white arrows) can be observed in the renal tissue from a vehicle treated mouse. Tubular dilation (yellow arrow) is still present after BDNF treatment, but protein casts are no more visible, and glomeruli have a normal appearance. These features can be better appreciated at higher magnification (lower panels, scale bars 50μm).

B) Transmission (upper panels) and scanning (lower panels) electron microscopy pictures show completely flattened podocyte processes from a vehicle-treated animal, and their almost normal appearance after BDNF treatment (scale bars: 5μm).