Table 2.
Volume and number of SWI-filtered phase WM lesions at baseline and change from baseline to week 12 and week 24.
| Baseline |
Week 12 change from baseline |
Week 24 change from baseline |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Patients with RRMS | HCs | p valuea | Patients with RRMS | HCs | p valuea | Patients with RRMS | HCs | p valuea | |
| Volume on SWI-filtered phase in mm3, mean (SD) | 2,620 (2,289.6) | 175 (160.5) | <0.001 | −271 (895.1) | −32 (130.1) | NS | −849 (1,479.4)b | −63 (154.5) | 0.011c |
| n (missing) | 22 (1) | 14 (1) | 22 (1) | 14 (1) | 21 (2) | 12 (3) | |||
| Number of lesions on SWI-filtered phase, mean (SD) | 17.4 (14.47) | 2.6 (1.45) | <0.001 | −0.6 (3.78) | −0.2 (1.52) | NS | −4 (8.1)b | −1 (1.4) | NS |
| n (missing) | 22 (1) | 15 (0) | 22 (1) | 15 (0) | 21 (2) | 13 (2) | |||
| Volume on SWI + PD/T2/FLAIR in mm3, mean (SD) | 1,342 (1,555.9) | – | – | −185 (539.0) | – | −610 (1,243.0)b,c | |||
| n (missing) | 22 (1) | 0 (15) | 22 (1) | 0 (15) | 20 (3) | 0 (15) | |||
| Number of lesions on SWI + PD/T2/FLAIR, mean (SD) | 16.6 (15.03) | 0.0 (0.00) | <0.001 | –0.9 (4.29) | 0.0 (0.00) | NS | −4.9 (10.21)b,c | 0.0 (0.00) | 0.001 |
| n (missing) | 22 (1) | 15 (0) | 22 (1) | 15 (0) | 21 (2) | 13 (2) | |||
| Volume on SWI + T1WI in mm3, mean (SD) | 788 (1,047.3) | – | – | −91 (422.1) | – | −305 (785.1) | – | ||
| n (missing) | 20 (3) | 0 (15) | 20 (3) | 0 (15) | 20 (3) | 0 (15) | |||
| Number of lesions on SWI + T1WI, mean (SD) | 10.8 (11.20) | 0.0 (0.00) | <0.001 | 0.2 (3.54) | 0.0 (0.00) | NS | −3.6 (8.22)b,c | 0.0 (0.00) | 0.003 |
| n (missing) | 22 (1) | 15 (0) | 22 (1) | 15 (0) | 21 (2) | 13 (2) | |||
a
For the difference between patients and HCs from the Wilcoxon rank-sum test.
b
Significant difference from zero within group from the Wilcoxon signed-rank test.
c
Not significant after adjustment for multiple comparisons with the Holm–Bonferroni correction. Comparisons at baseline were not adjusted for multiple comparisons.
FLAIR, fluid-attenuated inversion recovery; HC, healthy control; NS, not significant; PD, proton density; RRMS, relapsing–remitting multiple sclerosis; SD, standard deviation; SWI, susceptibility-weighted imaging; T1WI, T1 weighted image; WM, white matter.