Table 4.
Regional normalized SDGM volumes at baseline and percentage change from baseline at week 24.
| Baseline volume (mm3) |
% change from baseline at week 24 |
||||||
|---|---|---|---|---|---|---|---|
| Patients with RRMS |
HCs |
Patients with RRMS |
HCs |
||||
| Mean (SD) | Mean (SD) | p valuea | Mean (SD) | p valueb | Mean (SD) | p valuea | |
| n (missing) | 23 (0) | 15 (0) | 21 (2) | 13 (2) | |||
| SDGM | 42,620 (4,475) | 46,934 (2,748) | 0.002 | −2.09 (2.81) | <0.001 | 0.20 (1.82) | 0.011c |
| Caudate | 6,526 (987) | 7,002 (622) | NS | −1.53 (5.09) | 0.039c | −2.12 (5.28) | NS |
| Putamen | 9,076 (1,111) | 10,091 (750) | 0.004 | −4.55 (10.93) | 0.012c | 0.58 (3.298) | NS |
| Globus pallidus | 3,250 (386) | 3,575 (182) | 0.009 | −0.79 (5.72) | NS | −0.54 (4.36) | NS |
| Thalamus | 13,908 (1,743) | 15,551 (1,294) | 0.004 | −1.44 (1.76) | <0.001 | 0.06 (1.96) | NS |
| Hippocampus | 6,931 (658) | 7,315 (563) | NS | −1.71 (4.78) | NS | 2.07 (5.04) | 0.041c |
a
For the difference between patients with RRMS and HCs from the Wilcoxon rank-sum test.
b
For the difference from zero within patient group from the Wilcoxon signed-rank test.
c
Not significant after adjustment for multiple comparisons with the Holm–Bonferroni correction. Comparisons at baseline were not adjusted for multiple comparisons.
HC, healthy control; NS, not significant; RRMS, relapsing–remitting multiple sclerosis; SD, standard deviation; SDGM, subcortical deep-gray matter.