Table 3.
General comorbidity prevalence of the evaluated cohorts during 2011 and univariate odds ratios (ORs) for a fibromyalgia (FM) diagnosis
| Comorbid condition | Patients, n (%)
|
OR (95% CI) | P | |
|---|---|---|---|---|
| FM (n=4,296) | No-FM (n=583,665) | |||
| Any musculoskeletal pain condition | 2,871 (66.8) | 230,549 (39.5) | 3.1 (2.9, 3.3) | <0.0001 |
| Lupus | 93 (2.2) | 2,752 (0.5) | 4.7 (3.8, 5.8) | <0.0001 |
| Diffuse diseases of connective tissue | 45 (1.0) | 1,384 (0.2) | 4.5 (3.3, 6.0) | <0.0001 |
| Arthritis/other arthropathies | 1,498 (34.9) | 103,034 (17.7) | 2.5 (2.3, 2.7) | <0.0001 |
| Rheumatoid arthritis | 123 (2.9) | 5,720 (1.0) | 3.0 (2.5, 3.6) | <0.0001 |
| Osteoarthritis | 659 (15.3) | 47,005 (8.1) | 2.1 (1.9, 2.2) | <0.0001 |
| Low-back pain | 1,390 (32.4) | 73,543 (12.6) | 3.3 (3.1, 3.5) | <0.0001 |
| Back, neck pain (excluding low-back pain) | 867 (20.2) | 38,056 (6.5) | 3.6 (3.4, 3.9) | <0.0001 |
| Rheumatism (excluding the back) | 1,337 (31.1) | 94,477 (16.2) | 2.3 (2.2, 2.5) | <0.0001 |
| Other musculoskeletal pain conditions | 726 (16.9) | 54,963 (9.4) | 2.0 (1.8, 2.1) | <0.0001 |
| Any neuropathic pain condition | 724 (16.9) | 36,225 (6.2) | 3.1 (2.8, 3.3) | <0.0001 |
| Postherpetic neuralgia | 7 (0.2) | 648 (0.1) | 1.5 (0.7, 3.1) | 0.3417 |
| Carpal-tunnel syndrome | 106 (2.5) | 6,384 (1.1) | 2.3 (1.9, 2.8) | <0.0001 |
| Causalgias | 72 (1.7) | 2,802 (0.5) | 3.5 (2.8, 4.5) | <0.0001 |
| Neuritis radiculitis | 79 (1.8) | 3,152 (0.5) | 3.5 (2.8, 4.3) | <0.0001 |
| Trigeminal neuralgia | 15 (0.3) | 649 (0.1) | 3.1 (1.9, 5.3) | 0.0002 |
| Atypical facial pain | 7 (0.2) | 336 (0.1) | 2.8 (1.3, 6.0) | 0.0195 |
| Phantom-limb pain | 2 (,0.1) | 87 (,0.1) | 3.1 (0.8, 12.7) | 0.1778 |
| Autonomic neuropathies | 6 (0.1) | 482 (0.1) | 1.7 (0.8, 3.8) | 0.2384 |
| Mononeuritis of lower limb | 47 (1.1) | 2,341 (0.4) | 2.7 (2.1, 3.7) | <0.0001 |
| Other polyneuropathies | 66 (1.5) | 3,928 (0.7) | 2.3 (1.8, 2.9) | <0.0001 |
| Back, neck pain with neuropathic involvement (excluding low-back pain) | 462 (10.8) | 21,082 (3.6) | 3.2 (2.9, 3.5) | <0.0001 |
| Any sleep disorder | 653 (15.2) | 29,385 (5.0) | 3.4 (3.1, 3.7) | <0.0001 |
| Insomnia/sleep disorder, apnea | 593 (13.8) | 26,941 (4.6) | 3.3 (3.0, 3.6) | <0.0001 |
| Restless-leg syndrome | 97 (2.3) | 3,403 (0.6) | 3.9 (3.2, 4.8) | <0.0001 |
| Any mental disorder | 1,305 (30.4) | 77,869 (13.3) | 2.8 (2.7, 3.0) | <0.0001 |
| Depression | 910 (21.2) | 49,925 (8.6) | 2.9 (2.7, 3.1) | <0.0001 |
| Anxiety/generalized anxiety disorder | 683 (15.9) | 39,479 (6.8) | 2.6 (2.4, 2.8) | <0.0001 |
| Bipolar disorder | 67 (1.6) | 3,277 (0.6) | 2.8 (2.2, 3.6) | <0.0001 |
| Panic disorder | 82 (1.9) | 3,382 (0.6) | 3.3 (2.7, 4.2) | <0.0001 |
| Post-traumatic stress disorder | 52 (1.2) | 1,606 (0.3) | 4.4 (3.4, 5.9) | <0.0001 |
| Fatigue | 756 (17.6) | 41,872 (7.2) | 2.8 (2.6, 3.0) | <0.0001 |
| Headache/migraine | 761 (17.7) | 37,507 (6.4) | 3.1 (2.9, 3.4) | <0.0001 |
| Dyspareunia | 22 (0.5) | 943 (0.2) | 3.2 (2.1, 4.9) | <0.0001 |
| Tinnitus | 29 (0.7) | 3,443 (0.6) | 1.1 (0.8, 1.7) | 0.4779 |
| Chest pain | 875 (20.4) | 57,241 (9.8) | 2.4 (2.2, 2.5) | <0.0001 |
| Temporomandibular joint disorder | 47 (1.1) | 1,478 (0.3) | 4.4 (3.3, 5.8) | <0.0001 |
| Memory loss | 89 (2.1) | 5,113 (0.9) | 2.4 (1.9, 3.0) | <0.0001 |
| Abnormal involuntary movements | 67 (1.6) | 2,628 (0.5) | 3.5 (2.7, 4.5) | <0.0001 |
| Obesity | 466 (10.8) | 36,553 (6.3) | 1.8 (1.7, 2.0) | <0.0001 |
| Morbid obesity | 177 (4.1) | 9,728 (1.7) | 2.5 (2.2, 3.0) | <0.0001 |
| Interstitial cystitis | 12 (0.3) | 613 (0.1) | 2.7 (1.5, 4.7) | 0.0037 |
| Any gastrointestinal disorder | 1,676 (39.0) | 114,857 (19.7) | 2.6 (2.5, 2.8) | <0.0001 |
| Irritable bowel syndrome | 191 (4.4) | 7,169 (1.2) | 3.7 (3.2, 4.3) | <0.0001 |
| Gastroesophageal reflux disease/gastric/duodenal/other gastrointestinal disorder | 1,626 (37.8) | 112,098 (19.2) | 2.6 (2.4, 2.7) | <0.0001 |
Abbreviation: CI, confidence interval.