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. 2015 Mar 5;11:565–574. doi: 10.2147/NDT.S74898

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© 2015 Zhao et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Differential regulation of TCA cycle gene products in the oldest-old and young-old subjects as a function of clinical dementia, as reflected by CDR.

Notes: Levels of mRNA for TCA cycle genes were analyzed from young-old and oldest-old postmortem brain samples (n=8/age/CDR) by qPCR. TCA cycle genes examined: (A) PDHA; (B) KGDH; (C) aconitase; (D) succinate CoA ligase (SUCLA2); (E) MDH; and (F) CS. Fold changes between groups were calculated using the ΔCt method. Statistical analyses were conducted in GraphPad Prism software, using linear regression. The straight line represents the best linear regression fit. *P<0.05, **P<0.01, ***P<0.001.

Abbreviations: PDHA, Pyruvate dehydrogenase α-1; OO, oldest-old; YO, youngest-old; CDR, clinical dementia rating; KGDH, α-ketoglutarate dehydrogenase; CoA, coenzyme A; MDH, malate dehydrogenase; TCA, tricarboxylic acid; qPCR, quantitative PCR; RNA, ribonucleic acid; CS, citrate synthase.