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. 2015 Mar 5;10:1769–1790. doi: 10.2147/IJN.S63155

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© 2015 Zia et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Hemolytic activity of AmB and AmB–PGA nanoparticles. The extent of damage caused to red blood cells by the AmB formulation was measured as percent lysis of total erythrocytes used in the individual sample.

Notes: (A) Hemolysis caused by the AmB–PGA formulation after 1 hour of incubation with human red blood cells. (B) Hemolysis after a 24-hour incubation period. AmB-D, AmB-L and pure AmB used in preparation of the complex were used as controls. Data are pooled from three different experiments. Each datum point is a mean ± standard deviation.

Abbreviations: AmB, amphotericin B; DMSO, dimethyl sulfoxide; PGA, polyglutamic acid; AmB-D, Fungizone^®; AmB-L, Ambisome^®.