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. 2015 Mar 5;10:1769–1790. doi: 10.2147/IJN.S63155

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© 2015 Zia et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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In vitro cytotoxicity assay. Dose–response effects of AmB–PGA formulation on cytotoxicity against (A) KB cells and (B) RAW 264.7 cells.

Notes: The cells were exposed for 24 hours to various AmB formulations at different drug concentrations. MTT values were normalized to the control cells. The data are reported as the mean ± standard deviation of four experiments. Free drug is pure AmB used in preparation of the complex.

Abbreviations: AmB, amphotericin B; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; PGA, polyglutamic acid; AmB-D, Fungizone^®; AmB-L, Ambisome^®.