Table 2.

Effects of AmB–PGA on serum chemistry in mice

Groups	Creatinine (mg/dL)	ALT (IU/L)	AST (IU/L)	BUN (mg/dL)
Healthy control	0.18±0.01	30.2±5.90	97.5±8.19	21.6±1.4
AmB-D (5 mg/kg BW)	0.51±0.13	91.0±32.89	222.0±50.91	56.9±3.5
AmB–PGA (5 mg/kg BW)	0.12±0.02	32.0±5.09	130.21±6.29	20.8±0.07
AmB–PGA (10 mg/kg BW)	0.20±0.07	28.2±0.04	128.0±2.10	26.9±2.1
AmB–PGA (15 mg/kg BW)	0.22±0.03	36.7±1.34	139.0±2.56	22.1±0.5

Abbreviations: AmB, amphotericin B; AmB-D, Fungizone^®; ALT, alanine transaminase; AST, aspartate transaminase; BUN, blood urea nitrogen; BW, body weight; PGA, polyglutamic acid.