Table 3.
In vitro antifungal activity of various amphotericin B formulations
| Formulation |
Candida albicans (ATCC 18804)
|
Candida glabrata (MTCC 3019)
|
Candida albicans (ATCC 10231)
|
|||
|---|---|---|---|---|---|---|
| MIC (μg/mL) | MFC (μg/mL) | MIC (μg/mL) | MFC (μg/mL) | MIC (μg/mL) | MFC (μg/mL) | |
| AmB–PGA | 0.125 | 0.25 | 0.25 | 0.5 | 0.25 | 0.5 |
| AmB-D | 0.125 | 0.25 | 0.5 | 1.0 | 0.25 | 0.5 |
| AmB-L | 0.5 | 1.0 | 1.0 | 2.0 | 0.5 | 1.0 |
Abbreviations: AmB, amphotericin B; AmB-D, Fungizone®; AmB-L, Ambisome®; ATCC, American Type Culture Collection; PGA, polyglutamic acid; MIC, minimum inhibitory concentration; MFC, minimum fungicidal concentration; MTT, Microbial Type Culture Collection.