Table 2.
Correlations between the expression of HPV16 E6, p75NTR, PI3K, and clinical features in ESCC patients
| HPV16
|
p75NTR
|
PI3K
|
||||
|---|---|---|---|---|---|---|
| Negative | Positive | Negative | Positive | Negative | Positive | |
| Median age | ||||||
| ≤56 years | 18 | 38 | 22 | 34 | 21 | 35 |
| >56 years | 20 | 27 | 18 | 29 | 7 | 40 |
| P | 0.275 | 0.918 | 0.010 | |||
| Sex | ||||||
| Male | 26 | 58 | 31 | 53 | 23 | 61 |
| Female | 12 | 7 | 9 | 10 | 5 | 14 |
| P | 0.009 | 0.398 | 0.925 | |||
| Smoking status | ||||||
| Yes | 24 | 47 | 25 | 46 | 20 | 51 |
| No | 14 | 18 | 15 | 17 | 8 | 24 |
| P | 0.333 | 0.261 | 0.738 | |||
| Tumor differentiation | ||||||
| G1 | 0 | 7 | 1 | 6 | 1 | 7 |
| G2 | 29 | 49 | 37 | 41 | 23 | 55 |
| G3 | 9 | 9 | 2 | 16 | 5 | 13 |
| P | 0.066 | 0.007 | 0.243 | |||
| Infiltration depth | ||||||
| Submucosa | 4 | 6 | 2 | 8 | 4 | 6 |
| Superficial myoinvasion | 3 | 8 | 3 | 8 | 0 | 11 |
| Deep myoinvasion | 7 | 7 | 5 | 9 | 5 | 9 |
| Full thickness | 24 | 44 | 30 | 38 | 19 | 49 |
| P | 0.662 | 0.396 | 0.140 | |||
| Lymph node status | ||||||
| Negative | 18 | 33 | 18 | 33 | 11 | 40 |
| Positive | 20 | 32 | 22 | 30 | 17 | 35 |
| P | 0.739 | 0.465 | 0.205 | |||
| TNM staging | ||||||
| I | 2 | 5 | 2 | 5 | 4 | 3 |
| II | 22 | 36 | 16 | 42 | 7 | 51 |
| III | 14 | 21 | 19 | 16 | 17 | 18 |
| IV | 0 | 3 | 3 | 0 | 0 | 3 |
| P | 0.545 | 0.009 | 0.000 | |||
| General classification | ||||||
| Ulcerative type | 17 | 28 | 20 | 25 | 17 | 28 |
| Medullary type | 17 | 25 | 18 | 24 | 9 | 33 |
| Constrictive type | 0 | 1 | 0 | 1 | 1 | 0 |
| Fungating type | 4 | 11 | 2 | 13 | 2 | 13 |
| P | 0.634 | 0.084 | 0.097 | |||
| HPV16 | ||||||
| Negative | – | – | 28 | 10 | 14 | 24 |
| Positive | – | – | 12 | 53 | 14 | 51 |
| r and P | r=0.547, P<0.001 | r=0.364, P<0.001 | ||||
| p75NTR | ||||||
| Negative | – | – | – | – | 19 | 21 |
| Positive | – | – | – | – | 9 | 54 |
| r and P | r=0.166, P>0.05 | |||||
Abbreviations: ESCC, esophageal squamous cell carcinoma; HPV16, human papillomavirus 16; PI3K, phosphatidylinositol 3-kinase; p75NTR, low-affinity p75 neurotrophin receptor; TNM, tumor node metastasis.