Table 2.
Adherence (medication possession ratio ≥ 80%) of Patients Diagnosed With Localized Breast Cancer at Age ≥ 50 Years Who Received Adjuvant HT
| Factor | Adherent (n = 7,829) |
Nonadherent (n = 2,473) |
P* | Unadjusted OR |
Multivariable Analysis |
||||
|---|---|---|---|---|---|---|---|---|---|
| No. of Patients | % | No. of Patients | % | OR | 95% CI | OR | 95% CI | ||
| Race/ethnicity | < .001 | ||||||||
| White | 6,247 | 76.6 | 1,911 | 23.2 | 1.0 | 1.0 | |||
| Black | 678 | 71.2 | 274 | 28.8 | 0.76 | 0.55 to 0.88 | 0.87 | 0.74 to 1.01 | |
| Hispanic | 430 | 72.3 | 165 | 27.7 | 0.74 | 0.55 to 1.00 | 0.85 | 0.62 to 1.16 | |
| Asian | 182 | 82.0 | 40 | 18.0 | 1.29 | 0.85 to 1.97 | 1.38 | 0.90 to 2.11 | |
| Other | 292 | 77.9 | 83 | 22.1 | 1.07 | 0.84 to 1.38 | 1.03 | 0.80 to 1.32 | |
| Region | < .001 | ||||||||
| Northeast | 831 | 81.6 | 188 | 18.4 | 1.0 | 1.0 | |||
| West | 1,988 | 80.0 | 561 | 20.0 | 0.67 | 0.55 to 0.81 | 0.69 | 0.57 to 0.84 | |
| Midwest | 3,619 | 74.3 | 1,252 | 25.7 | 0.80 | 0.67 to 0.96 | 0.81 | 0.67 to 0.98 | |
| South | 1,387 | 74.8 | 468 | 25.2 | 0.65 | 0.55 to 0.78 | 0.68 | 0.57 to 0.81 | |
| Net worth | < .001 | ||||||||
| Low (< $250,000) | 2,427 | 71.7 | 958 | 28.3 | 1.0 | 1.0 | |||
| Medium ($250,000-$750,000) | 3,839 | 77.1 | 1,143 | 22.9 | 1.33 | 1.20 to 1.46 | 1.29 | 1.15 to 1.43 | |
| High (> $750,000) | 1,563 | 80.8 | 372 | 19.2 | 1.66 | 1.45 to 1.90 | 1.59 | 1.36 to 1.84 | |
| Household income | < .001 | ||||||||
| Low (< $40,000) | 1,544 | 72.5 | 585 | 27.5 | 1.0 | — | |||
| Medium ($40,000-$100,000) | 4,405 | 75.8 | 1,407 | 24.2 | 1.19 | 1.05 to 1.32 | — | ||
| High (> $100,000) | 1,880 | 79.7 | 481 | 20.4 | 1.48 | 1.29 to 1.70 | — | ||
| Adjusted 30-day copay | < .001 | ||||||||
| < $10 | 2,574 | 77.7 | 741 | 22.4 | 1.0 | 1.0 | |||
| $10-$20 | 2,311 | 76.9 | 695 | 23.1 | 0.96 | 0.85 to 1.08 | 0.99 | 0.88 to 1.10 | |
| > $20 | 2,944 | 74.0 | 1,037 | 26.0 | 0.82 | 0.73 to 0.91 | 0.90 | 0.80 to 1.01 | |
| Medicare | < .001 | ||||||||
| No | 7,550 | 76.5 | 2,317 | 23.5 | 1.0 | 1.0 | |||
| Yes | 279 | 64.1 | 156 | 35.9 | 0.55 | 0.45 to 0.67 | 0.58 | 0.46 to 0.72 | |
| Education | .009 | ||||||||
| < High school | 2,095 | 74.2 | 729 | 25.8 | 1.0 | 1.0 | |||
| > High school | 5,734 | 76.7 | 1,744 | 23.3 | 1.14 | 1.04 to 1.26 | 0.94 | 0.84 to 1.06 | |
| Age at HT initiation, years | .001 | ||||||||
| 50-55 | 2,219 | 74.3 | 767 | 25.7 | 0.85 | 0.75 to 0.94 | 0.85 | 0.77 to 0.95 | |
| 56-65 | 4,031 | 77.3 | 1,182 | 22.7 | 1.0 | 1.0 | |||
| 66-75 | 1,072 | 76.7 | 326 | 23.3 | 0.96 | 0.84 to 1.11 | 1.08 | 0.93 to 1.26 | |
| ≥ 75 | 507 | 71.9 | 198 | 28.1 | 0.75 | 0.63 to 0.90 | 0.88 | 0.73 to 1.07 | |
| Year of HT initiation | < .001 | ||||||||
| 2007 | 1,094 | 73.4 | 396 | 26.6 | 1.0 | 1.0 | |||
| 2008 | 1,956 | 73.6 | 701 | 26.4 | 1.01 | 0.87 to 1.17 | 1.03 | 0.89 to 1.20 | |
| 2009 | 1,992 | 75.0 | 663 | 25.0 | 1.09 | 0.94 to 1.26 | 1.10 | 0.95 to 1.28 | |
| 2010 | 1,962 | 78.9 | 525 | 21.1 | 1.35 | 1.16 to 1.57 | 1.36 | 1.17 to 1.59 | |
| 2011 | 825 | 81.4 | 188 | 18.6 | 1.59 | 1.31 to 1.93 | 1.54 | 1.26 to 1.89 | |
| Mastectomy | .356 | ||||||||
| No | 3,877 | 75.6 | 1,251 | 24.4 | 1.0 | 1.0 | |||
| Yes | 3,952 | 76.4 | 1,222 | 23.6 | 1.04 | 0.95 to 1.14 | 1.10 | 1.00 to 1.21 | |
| No. of comorbidities | .021 | ||||||||
| 1-5 | 6,334 | 76.5 | 1,948 | 23.5 | 1.0 | 1.0 | |||
| ≥ 6 | 1,495 | 74.0 | 525 | 26.0 | 0.88 | 0.78 to 0.98 | 0.88 | 0.79 to 0.99 | |
| Physician specialty | .867 | ||||||||
| Hematology-oncology | 5,612 | 75.9 | 1,777 | 24.1 | 0.99 | 0.90 to 1.10 | — | ||
| Other | 2,217 | 76.1 | 696 | 23.9 | 1.0 | — | |||
Abbreviations: HT, hormonal therapy; OR, odds ratio.
*
χ2 statistical comparison across total distribution of selected characteristics.