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. 2014 Dec 16;20(2):154–161. doi: 10.1038/mp.2014.162

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Copyright © 2015 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Immunofluorescence and confocal imaging. Parvalbumin (PV) interneurons enwrapped with perineuronal net contain metallopeptidase protein. Colocalization of PV, somatostatin (Sst), Wisteria floribunda agglutinin (WFA), Mme (Neprilysin), Adamts8 and Mybpc1. (a) Micrograph of parvalbumin interneurons (red) revealing that most PV coexpressed with Sst (green) are void of perineuronal net (WFA; blue). (b) Parvalbumin interneurons (red) enwrapped with perineuronal net (blue) contain Neprilysin (Mme; green). (c) Adamts8 (red) can be found in all parvalbumin interneurons (green), but not exclusively. (d) The majority of parvalbumin interneurons (red) enwrapped by perineuronal net (blue) colocalize with Mybpc1 (green). (e) Somatostatin-positive neurons (red) are not enwrapped by perineuronal net (WFA, blue) and do not colocalize with Mybpc1 (green). Scale bar, 80 μm in low ( × 10) and 30 μm in high ( × 63) magnification. Arrows depicts main cell of interests (red). This observation was confirmed in three male 40-day-old C57/Bl6 mice.