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Number of differential metabolites in single-R and CTR L. donovani lines compared to those in the WTM line. The resistance index (RI) against AmB, MIL, SbIII, and PMM, respectively, is mentioned for each single-R line (A, M, S, and P) and CTR line (RI/RI) (AS, SP, AM, MP, and AP) (adapted from García-Hernández et al. [28]). Differential metabolites (Δmb) are either increased or decreased (fold change, <0.5 or >2 and P < 0.05 and P < q).
