TABLE 3.
Mean isavuconazole plasma pharmacokinetic parametersa
| Parameterd | Low-dose cohortb |
High-dose cohortc |
||
|---|---|---|---|---|
| Day 1 (n = 10) | Day 7 (n = 8)e | Day 1 (n = 11) | Day 7 (n = 10) | |
| C12 (μg/ml) | 1.5 (0.4) | 2.5 (0.8) | ||
| Cmax (μg/ml) | 3.6 (1.0) | 8.0 (2.8) | ||
| AUC0–24 (μg · h/ml) | 60.1 (22.3) | 113.1 (19.6) | ||
a
PK analysis set; values reflect mean (standard deviation [SD]).
b
Isavuconazole administered as a 200-mg once-daily maintenance regimen.
c
Isavuconazole administered as a 400-mg once-daily maintenance regimen.
d
C12, plasma concentration at 12 h after the start of treatment; Cmax, maximum plasma concentration of drug; AUC0–24, area under the plasma concentration-time curve from time 0 to 24 h after the initiation of isavuconazole intake.
e
For AUC0–24, n = 7.