FIG 10.

Possible mechanism by which QC induces FCZ-mediated apoptotic cell death in FCZ-resistant C. albicans NBC099. To summarize our research, QC inhibited farnesol-mediated hyphal development, biofilm formation, and production of virulence factors in C. albicans NBC099 cells. Moreover, QC was found to inhibit adenylate cyclase activity in NBC099, a key enzyme responsible for suppression of farnesol production. Later, QC increased the sensitization of NBC099 cells to FCZ, thereby inducing cell death and eventually apoptotic cell death.