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Probabilities of target attainment (PTA) versus MIC derived from simulations of moxifloxacin administration. (A) Simulations of p.o. moxifloxacin at 400 mg q.d. (B) Simulations of i.v. moxifloxacin at 400 mg q.d. fAUC24/MIC > 34 = PK-PD target adopted for Gram-positive pathogens. fAUC24/MIC > 75 = PK-PD target adopted for Gram-negative and atypical pathogens. The dotted lines represent PTA 90%.
