TABLE 2.
Pharmacokinetic parameters corresponding to the one-compartment population model depicted in Fig. 1a
| Parameter | Estimate (RSE %) | IIV (RSE %) | Description |
|---|---|---|---|
| CL × (wt/70)0.75 (liters/h) | 12 (10) | 21 (26)b | Systemic clearance with allometric wt scaling |
| V × (wt/70) (liters) | 165 (13) | Central vol of distribution with allometric wt scaling | |
| F (%) | 89 (16) | 30 (29)c | Oral bioavailability |
| ka (h−1) | 5.4 (58) | Absorption rate constant | |
| σ1, prop error (%) | 34 (10) | Proportional residual error |
a
RSE, relative standard error reported on the approximate standard deviation scale; IIV, interindividual variability expressed as coefficient of variation; prop, proportional.
b
Shrinkage, 20%; Etabar (statistical significance of the mean ETA being zero) P = 0.01.
c
Shrinkage, 25%; Etabar P = 0.007.