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S. cerevisiae homology models depicting possible interactions between ELQs and cyt bc1. Shown are the predicted interactions between the 1-NH group of ELQ-110 and the E272 residue at the Qo site (A) and hydrogen bonding of the 1-NH group of ELQ-300 to the Qi site D229 residue (B), showing the 6-position chlorine in close proximity to the isoleucine residue mutated in the P. falciparum D1 clone. The dashed blue lines represent predicted hydrogen bonds.
