TABLE 3.

Comparative activities of 3-diarylether ELQs containing 6-position halogens and 7-position OCH₃ groups

ELQ	Substituent at position:			IC50 value (nM) or ratio fora:
	3	6	7	Dd2	C2B/Dd2	D1/Dd2
271	DAEb	H	H	12	2.8	0.2
298	DAE	H	OCH3	5.5	0.7	0.8
314	DAE	F	H	33	1.3	3.4
316	DAE	F	OCH3	3.1	1.1	3.6
296	DAE	Cl	H	29	0.9	16
300	DAE	Cl	OCH3	6.6	0.7	24
339	DAE	Br	H	170	1.1	14
340	DAE	Br	OCH3	25	0.4	65

^aIC₅₀ values were averaged from ≥3 independent experiments run in triplicate. The standard deviations were <10%.

^bDAE, para-OCF₃ diaryl ether side chain, as present in ELQ-300.