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Example of pharmacokinetic profiles of 2 different single doses of ceftazidime (codosed with avibactam) in plasma and ELF of neutropenic mice with thigh infection (left panel, 16 mg/kg dose) or lung infection (right panel, 32 mg/kg dose). Filled and open squares, concentrations in plasma and ELF, respectively, in the thigh model; filled and open circles, concentrations in plasma and ELF, respectively, in the lung model (each dose group consisted of two mice).
