TABLE 2.
Mutations in embCAB among 139 MDR-TB isolates
| Mutations in: |
No. of isolates |
|||
|---|---|---|---|---|
| embC | embA | embB | EMB resistant (n = 79) | EMB susceptible (n = 60) |
| Arg738Gln | 0 | 1 | ||
| C(−16)A | 0 | 1 | ||
| G(−43)Ca | 1 | 0 | ||
| Gly154Sera | 0 | 1 | ||
| Thr270Proa | 0 | 1 | ||
| Ala291Thra | 0 | 1 | ||
| Gly554Aspa | 1 | 0 | ||
| Val417Meta | Thr652Lysa | 0 | 1 | |
| Pro763Sera | 0 | 1 | ||
| C(−16)A | Val50Alaa/Gln497Pro | 1 | 0 | |
| C(−16)G | Val50Alaa/Gln497Lys | 1 | 0 | |
| C(−16)G | Met306Ile | 1 | 0 | |
| C(−16)T | Met306Ile | 1 | 0 | |
| Met306Ile/Asp354Ala | 1 | 0 | ||
| Met306Ile/Gly406Ser | 1 | 0 | ||
| Met306Ile/Thr643Ilea | 1 | 0 | ||
| Met306Ile | 14 | 5 | ||
| C(−16)T | Met306Leu | 1 | 0 | |
| Met306Leu | 2 | 2 | ||
| Met306Val/Ile563Leu | 0 | 1 | ||
| Met306Val/Pro907Sera | 0 | 1 | ||
| Met306Val/Asp1024Asn | 1 | 0 | ||
| C(−12)T | Met306Val | 1 | 0 | |
| Pro150Sera | C(−12)T/Ala331Thra | Met306Val | 1 | 0 |
| C(−16)T | Met306Val | 1 | 0 | |
| Asp4Asn | Met306Val | 1 | 0 | |
| Pro769Thra | Met306Val | 1 | 0 | |
| Gln725Arga | Met306Val | 1 | 0 | |
| Val885Meta | Met306Val | 0 | 1 | |
| Met306Val | 21 | 5 | ||
| Tyr319Asp | 1 | 0 | ||
| C(−11)A | Tyr319Cys | 1 | 0 | |
| Tyr319Cys | 1 | 0 | ||
| Asp328Tyr | 1 | 0 | ||
| C(−8)T/Gly200Ser | Asp354Asn/Ala679Thra | 1 | 0 | |
| C(−12)T | Asp354Ala | 1 | 0 | |
| Asp354Ala | 0 | 1 | ||
| Asp354Asn | 0 | 1 | ||
| G(−43)Ca | Asn399Thr | 1 | 0 | |
| Gly406Ala | 4 | 2 | ||
| Glu951Aspa | Gly406Asp | 0 | 1 | |
| Gly406Asp | 2 | 2 | ||
| C(−16)A | Gly406Ser | 1 | 0 | |
| Gly406Ser | 2 | 0 | ||
| Ser412Proa | 1 | 0 | ||
| Val42Alaa | Gln497Arg | 0 | 1 | |
| Gln497Arg | 1 | 1 | ||
| Gln497Lys | 1 | 1 | ||
| Ile563Leu | 0 | 1 | ||
| C(−16)G | Gly603Arga | 0 | 1 | |
| Thr642Alaa/His1002Arg | 1 | 0 | ||
| His1002Arg | 1 | 0 | ||
| Asp1024Asn | 1 | 0 | ||
a
Mutation not previously reported.