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Effects of integrase substitutions on stHIV-1(SCA,SVIF) infectivity in TZM-bl cells. StHIV-1 infectiousness was measured by quantifying luciferase activity in terms of relative luminescent units (RLU) produced by TZM-bl cells at 48 h after infection with increasing concentrations of virus as measured by RT activity (as counts per minute [cpm], x axis). Means and standard error of the means (SEM) are presented. Lines are fits.
