TABLE 3.
Values of MSD, α, and Deff of COOH-PS in different mediab
| Sample | MSD μm2 at 1 s | α | Deff (μm2/s) at 1 s | Deff/Dw |
|---|---|---|---|---|
| Water | 1.09 | 1 | 0.26 | 1 |
| HEC (1.5 wt%) | 0.07 | 56 × 10−3 | 0.017 | 0.065 |
| Macaque CVMa | 1.66 × 10−4 | 0.070 × 10−3 | 3.95 × 10−5 | 15.19 × 10−5 |
| F127-F68-HPMC (22.5/2.5/1 wt%, respectively) | 1.18 × 10−4 | 0.020 × 10−3 | 2.80 × 10−5 | 10.76 × 10−5 |
| F127-HPMC (20/1 wt%, respectively) | 0.53 × 10−4 | 0.009 × 10−3 | 1.27 × 10−5 | 4.88 × 10−5 |
a
Data reported for particles stationary in mucus.
b
The slope α of each MSD curve was determined by fitting MSD to the equation MSD = 4 D0τα.