TABLE 3.
Pharmacokinetic parameters for SEVM and SBM
| Parameter and regimen | Mean Cmaxa (mg/liter) (SD) | Mean Cminb (mg/liter) (SD) | Mean half-life (h) (SD) |
|---|---|---|---|
| Total concns (SEVM) | |||
| DAP (6 mg/kg) | 83.2 (6.3) | 11.3 (3.7) | 8.6 (10.2) |
| DAP (8 mg/kg) | 138.4 (9.8) | 18.6 (5.4) | 7.5 (0.9) |
| VAN | 38.1 (2.1) | 11.5 (1.3) | 7.4 (2.3) |
| LZD | 19.6 (4.3) | 3.2 (1.4) | 4.6 (1.1) |
| Free concns (SBM) | |||
| DAP (6 mg/kg) | 6.03 (1.05) | 0.96 (0.5)c | 8.9 (1.5) |
| DAP (8 mg/kg) | 9.0 (1.5) | 1.4 (0.6)c | 7.7 (1.8) |
| VAN | 16.6 (1.9) | 5.9 (1.5) | 7.0 (1.4) |
| LZD | 13.3 (2.7) | 2.03 (0.9) | 5.2 (0.7) |
a
Cmax, maximum concentration.
b
Cmin, minimum concentration.
c
Extrapolated values.