TABLE 3.

Physical, chemical, and pharmacokinetic properties of HTS hit, compound A, and amoxicillin

Property	HTS hit	Compound A	Amoxicillin
Solubility (μM)	<0.6	1,365	>1,000
ClogP	5.35	3.13	−1.87
Protein binding (% bound)
Mouse	NDa	86	ND
Human	99.7	82	<30
Microsomal clearance (μl/min/mg)
Mouse	>100	30	ND
Human	43	13	<4
Rat pharmacokinetics
Clearance (ml/min/kg)	99	25	16b
t1/2 (h)c	1.5	0.5	0.9b
Bioavailability (%)	ND	39	51b

^aND, not determined.

^bData taken from reference 33.

^ct_1/2, elimination half-life.