TABLE 1.
Antimicrobial susceptibility of S. aureus HG001 and antimicrobial concentrationsa
| Antimicrobial | MIC (mg/liter) | Usual plasmatic concn (mg/liter) | Usual bone/plasma ratio | Concn (mg/liter)b |
||
|---|---|---|---|---|---|---|
| Cmin | Cbone | Cmax | ||||
| Beta-lactams | ||||||
| Oxacillin | 0.094 | 50 | 0.17 | 3.33 | 10 | 30 |
| Ceftaroline | 0.19 | 20 | 0.19 | 1.33 | 4 | 12 |
| Clindamycin | 0.032 | 4−14 | 0.35 | 1.33 | 4 | 12 |
| Fosfomycin | 2 | 4−14 | 0.35 | 1.33 | 4 | 12 |
| Glyco/lipopeptides | ||||||
| Vancomycin | 1.5 | 20–40 | 0.21 | 2 | 6 | 18 |
| Teicoplanin | 1.5 | 10–70 | 0.21 | 1 | 3 | 9 |
| Daptomycin | 0.19 | 4–11 | 0.24 | 1.7 | 5 | 15 |
| Linezolid | 1 | 20 | 0.4 | 2.67 | 8 | 24 |
| Ofloxacin | 0.5 | 5 | 0.5 | 0.67 | 2 | 6 |
| Rifampin | 0.004 | 10–30 | 0.27 | 2 | 6 | 18 |
| Tigecycline | 0.125 | 0.2–1.5 | 0.35 | 0.1 | 0.3 | 0.9 |
a
MICs were determined by using the standard diffusion method (Etest). Usual plasmatic and bone/plasma concentration ratios were determined after a literature review, especially from the review of Landersdorfer et al. (19).
b
Cbone, bone concentration; Cmin, minimal concentration; Cmax, maximal concentration.